Professor of Behavioral Biology in Psychiatry & Pediatrics
Research Chief, Developmental Neuroscience
New York State Psychiatric Institute

1051 Riverside Drive, Unit 40
New York, NY 10032

Faculty Profile


Research Summary

Early Experience and Brain Development

Research in this laboratory is focused on understanding how both normal and abnormal variation in the environment during pregnancy and in the early postnatal period affects brain development. A large body of evidence supports the idea that vulnerability for physical and mental illnesses is shaped by events occurring during these sensitive periods of development. Interest in study of the proximal and long-term effects of early experiences emerged from the work of many researchers in the field of Developmental Psychobiology. Rapid advances in developmental neuroscience, genetics and molecular epigenetics now make it possible to study the developmental mechanism that account for enduring changes in risk and resilience to disease

Within the Conte Center, which was based on initial funding from the Sackler Institute, we continue to work on a project that focuses on the effects of SSRI antidepressant exposure during pregnancy and how naturally occurring genetic variation in regulation of synaptic reuptake of serotonin affects the development of brain structure and function of human infants. The renewal of the Conte Center, submitting in the spring of 2015, will expand these investigations and has a central core of work devoted to direct measures of infant brain activity as assessed by EEG.

Another major effort is a project supported by NICHD and NIAAA. This large network study is addressing the impact of Prenatal Alcohol exposure on Stillbirth and SIDS (PASS). The target enrollment of 12,000 women and children was reached in May of 2015. This study will provide the most comprehensive data base regarding early adverse exposure on risk for the most catastrophic outcomes related to abnormal brain function during early life.

We also continue collaborations with a group at Columbia conducting intervention trials in preterm infants (Nurture Science Program, Department of Pediatrics). The first completed trial of the Family Nurture Intervention resulted in strong findings showing increases in brain activity at term age and improved neurobehavioral outcomes to 18 months of age. The numerous EEG recordings from this study also revealed fundamental relationships between bursts of electrocortical activity early during the NICU stay as predictors of subsequent EEG activity at term age. These findings were used as critical preliminary results in the renewal application of our Conte Center.

Select Publications
  1. Myers MM, Grieve PG, Stark RI, Isler JR, Hofer MA, Yang J, Ludwig RJ, Welch MG. Family Nurture Intervention in preterm infants alters frontal cortical functional connectivity assessed by EEG coherence. Acta Paediatr. 2015 Jul;104(7):670-7.
  2. Welch MG, Firestein MR, Austin J, Hane AA, Stark RI, Hofer MA, Garland M, Glickstein SB, Brunelli SA, Ludwig RJ, Myers MM. Family Nurture Intervention in the Neonatal Intensive Care Unit improves social-relatedness, attention, and neurodevelopment of preterm infants at 18 months in a randomized controlled trial. J Child Psychol Psychiatry. 2015 Mar 11. [Epub ahead of print]
  3. Hane AA, Myers MM, Hofer MA, Ludwig RJ, Halperin MS, Austin J, Glickstein SB, Welch MG. Family nurture intervention improves the quality of maternal caregiving in the neonatal intensive care unit: evidence from a randomized controlled trial. J Dev Behav Pediatr. 2015 Apr;36(3):188-96.
  4. Welch MG, Halperin MS, Austin J, Stark RI, Hofer MA, Hane AA, Myers MM. Depression and anxiety symptoms of mothers of preterm infants are decreased at 4 months corrected age with Family Nurture Intervention in the NICU. Arch Womens Ment Health. 2015 Mar 1. [Epub ahead of print]
  5. Shair HN, Rupert DD, Rosko LM, Hofer MA, Myers MM, Welch MG. Effects ofmaternal deprivation and the duration of reunion time on rat pup ultrasonic vocalization responses to isolation: Possible implications for human infantstudies. Dev Psychobiol. 2015 Jan;57(1):63-72.
  6. Dukes KA, Burd L, Elliott AJ, Fifer WP, Folkerth RD, Hankins GD, Hereld D, Hoffman HJ, Myers MM, Odendaal HJ, Signore C, Sullivan LM, Willinger M, Wright C, Kinney HC; PASS Research Network. The safe passage study: design, methods, recruitment, and follow-up approach. Paediatr Perinat Epidemiol. 2014 Sep;28(5):455-65.
  7. Duncan JR, Garland M, Stark RI, Myers MM, Fifer WP, Mokler DJ, Kinney HC. Prenatal nicotine exposure selectively affects nicotinic receptor expression in primary and associative visual cortices of the fetal baboon. Brain Pathol. 2015 Mar;25(2):171-81.
  • 2U01HD055155 (Fifer, W.P. & Myers, M.M Co-PIs) 08/01/2011-07/31/2016NICHD

    “Prenatal Alcohol in Sudden Infant Death Syndrome and Stillbirth (PASS) Network”

    Co-operative Agreement for Physiological Assessment Center.

  • RO1HD32774 (Fifer, W.P., PI; Myers, M.M. Co-Inv) 04/01/11-03/30/16NICHD

    “Perinatal Assessment of At-Risk Populations”

    Investigations of underlying mechanisms and early assessment of risk for Sudden Infant Death.

  • MH090966 (Gingrich PI, Myers, Co-Inv) 09/01/2010- 08/31/15NIMH

    “Serotonin Signaling During Early Development”

    MRI and EEG correlates of genetic polymorphisms in the serotonin transporter and prenatal exposure to SSRIs.

Return to Members