Jonathan Posner, MD
Suzanne Crosby Murphy Associate Professor of Psychiatry at CUMC

1051 Riverside Drive, Unit 74
New York, NY 10032
Tel: 646-774-5863

Email: jonathan.posner@nyspi.columbia.edu
Faculty Profile: https://www.columbiapsychiatry.org/profile/jonathan-e-posner-md#overview

Research Summary

My research focuses on the use of MRI techniques to understand brain structure and function across a range of neuropsychiatric conditions in pediatric populations. I completed my clinical training in child and adolescent psychiatry, and then trained in developmental neuroscience and MRI methods at Columbia University. I have been awarded NIH funded grants to examine neural circuits related to attention, motivation, and emotional processing in a range of conditions including ADHD, anorexia nervosa, and familial depression. Currently, I am a principal investigator studies aimed at understanding the influence of psychosocial adversity on executive functions and related neural circuitry using MRI measures in infants and children.

Select Publications
  1. Lugo-Candelas C, Monk C, Duarte CS, Lee S, Posner J. Shared genetic factors, fetal programing, and the transmission of depression. Lancet Psychiatry, in press
  2. Posner J. The role of precision medicine in child psychiatry: What can we expect and when? Journal of the American Academy of Child and Adolescent Psychiatry, in press
  3. Lugo-Candelas C, Cha J, Hong S, Bastidas V, Weissman M, Fifer WP, Myers M, Talati A, Bansal R, Peterson BS, Monk C, Gingrich J, Posner J. Brain structure and connectivity in infants exposed to serotonin reuptake inhibitors during pregnancy, JAMA Pediatrics, 2018 April
  4. Bernanke J, Yun W, Posner J. Time-varying analyses of imaging data: Capturing the role of network dynamics in psychopathology, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2018, Mar
  5. Scorza P, Duarte C, Hipwell A, Posner J, Ortin-Peralta A, Canino G, Monk C. Intergenerational Transmission of Disadvantage: Epigenetics and Parents’ Childhoods as the First Exposure, Journal of Child Psychology and Psychiatry, 2018 Feb
  6. Weissman MM, Taladi A, Hao X, Posner J. Risks for Major Depression: Searching for Stable Traits, Biological Psychiatry, 2018 Jan
  7. Hao X, Talati A, Shankman SA, Liu J, Kaiser J, Tenke CE, Warner V, Wickramaratne PJ, Weissman MM, Posner J. Stability of cortical thinning in persons at increased familial risk for major depression across eight years, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2017 Oct
  8. Roy AK, Bennett R, Posner J, Hulvershorn L, Castellanos FX, Klein RG. Altered Intrinsic Functional Connectivity of the Cingulate Cortex in Children with Severe Temper Outbursts in Children, Development and Psychopathology, 2017 Aug 14
  9. Cha J, Guffanti G, Gingrich J, Talati A, Wickramaratne P, Weissman MM, Posner J. Effects of serotonin transporter gene variation on impulsivity is mediated by default mode network: A family study of depression. Cerebral Cortex, 2017
Grants

R01MH110445-01A1           Posner & Steinglass              04/2017-02/2022
NIMH
Longitudinal Assessment of Neural Circuits in Adolescents with Anorexia Nervosa
The study aims to examine the neural circuits related to restrictive caloric intake.
Role: Multiple Principal Investigator

R01MH036197-29A1           Posner & Weissman               04/2017­–02/2021
NIMH
Three generations at high and low risk for depression followed longitudinally
The study aims to understand mechanism by which depression passes from one generation to the next.
Role: Multiple Principal Investigator

UG3 OD023328                                    Duarte, Canino, Monk, & Posner 09/2016–08/2023
NIH
Breaking the cycle of intergenerational disadvantage: Neurodevelopment among Puerto Rican children
This study aims to examine the influence of psychosocial adversity on neurodevelopment.
Role: Multiple Principal Investigator

K01 MH109836                       Cha                                       09/2016-08/2020
NIMH
Neural correlates of fear over-generalization in youth with pathological anxiety
This study aims to examine mechanism underlying anxiety in adolescents
Role: Mentor

R01MH101172                         Posner                                  08/2013–07/2019  (NCE)
NIMH
Imaging Stimulant Effects on Emotional Lability in Children with ADHD
This study combines a randomized clinical trial of a stimulant medication with pre- and post-treatment MRI scanning. The aim of the study is to examine stimulant-induced effects of brain structure and function and how these stimulant-induced effects alter emotional lability in children with ADHD.
Role: Principal Investigator