My lab examines developmental plasticity in response to environmental experiences. We are particularly interested in the impact of early life experiences on behavior, the neural mechanisms associated with these environmentally mediated effects and the epigenetic changes that allow these effects to persist within and across generations.
- Franks B, Champagne FA, & Curley JP (in press) Postnatal maternal care predicts divergent weaning strategies and the development of social behavior. Developmental Psychobiology
- Stolzenberg DS, Champagne FA (in press) Hormonal and non-hormonal bases of maternal behavior: The role of experience and epigenetic mechanisms. Hormones & Behavior
- Kundakovic M, Gudsnuk K, Herbstman JB, Tang D, Perera FP, Champagne FA (in press) DNA methylation of BDNF as a biomarker of early-life adversity. Proc Natl Acad Sci U S A
- Jensen Peña C, Champagne FA (in press) Neonatal over-expression of estrogen receptor-α alters midbrain dopamine neuron development and reverses the effects of low maternal care in female offspring. Developmental Neurobiology
- Champagne FA, Curley JP (in press) Epigenetic effects of parental care within and across generations. In: The Family Emotional System: An Integrative Concept for Theory, Science and Practice. Lexington Books.
- Braithwaite EC, Kundakovic M, Ramchandani PG, Murphy SE, Champagne FA (2015) Maternal prenatal depressive symptoms predict infant NR3C1 1F and BDNF IV DNA methylation. Epigenetics.10(5):408-17.
- Braun K, Champagne FA (2015) Paternal influences on offspring development: behavioural and epigenetic pathways. Neuroendocrinology. 26(10):697-706.
- Kundakovic M, Champagne FA (2015) Early Life Experience, Epigenetics, and the Developing Brain. Neuropsychopharmacology. 40(1):141-53.
- Yan Z, Zhang H, Maher C, Arteaga-Solis E, Champagne FA, Wu L, McDonald JD, Yan B, Schwartz GJ, Miller RL (2014) Prenatal Polycyclic Aromatic Hydrocarbon, Adiposity, Peroxisome Proliferator-Activated Receptor (PPAR) γ Methylation in Offspring, Grand-Offspring Mice. PLoS One. 9(10):e110706.
- Tang G, Gudsnuk K, Kuo SH, Cotrina M, Rosoklija G, Sosunov A, Sonders M, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne FA, Dwork A, Goldman J, Sulzer D (2014) Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron 83(5):1131-43.
- NIMH 1P50MH090964-01A1 (Mann) 2013-2018Antecedents of Suicidal Behavior Related Neurobiology
The Conte Center will employ a multidisciplinary approach to study how reported childhood adversity can mold the diathesis for suicidal behavior. These projects will help elucidate how early adverse experiences affect gene expression and brain biology to increase risk of suicidal behavior later in life.
- NIH – R01 (Co-Investigator with Monk C & Tycko B) 2011-2016Prenatal stress: The epigenetic basis of maternal and perinatal effects
This project combines research in humans and in a rodent model exploring the link between prenatal stress, epigenetic dysregulation, and offspring development.
- 1P50HG007257-01 Champagne (Co-PI; Steering Committee) 2014-2018Center for ELSI Research on Psychiatric, Neurologic, and Behavioral Genetics (P50)
This project is aimed at establishing a center for studies on the ethical, social, legal implications of studies of genetic risk of neurological, psychiatric, and behavioral disorders.
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